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Elsevier's PharmaPendium Introduces The FDA Classic Collection
PharmaPendium, Elsevier"s online re for authoritative preclinical, clinical and post-marketing drug information, has significantly expanded its coverage of US Food and Drug Administration (FDA) approval documents with the launch of the FDA Classic Collection. This collection contains all available historical FDA approval documents up to and including those issued in 1991 - all indexed and made searchable for the first time in history. With the addition of the FDA Classic Collection, PharmaPendium has become the only integrated, searchable of all FDA drug approval documents.

Antioxidants Affect Semen Quality
Low antioxidant intake is associated with low reproductive capacity in semen. This is the finding of a new study carried out in two infertility centres in Alicante and Murcia, and which has been published online in the journal Fertility and Sterility.
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Weight Loss In Old Age May Signal Dementia
A new study shows that older people who are thinner or are losing weight quickly are at a higher risk of developing dementia, especially if they started out overweight or obese. The research is published in the May 19, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Public Health

Anemia Associated With Greater Risk Of Death In Heart Disease Patients

A new study appearing in Congestive Heart Failure has found that the presence of anemia in patients with chronic heart failure is associated with a significantly increased risk of death. The findings also show that anemia is associated with a poorer degree of left ventricular function and a lower left ventricular ejection fraction, an objective measure of cardiac function. Heart failure is a common and serious chronic illness. A large number of patients with heart failure also have anemia, which is most likely a complication from poor heart function. The aim of this study was to assess the impact of anemia on the clinical outcomes of chronic heart failure (CHF) by a meta-analysis and systemic review of published literature. A total of 97,699 patients with CHF were identified from the published studies. From a collective analysis, researchers found that when anemia occurs, it worsens patient prognosis, making them more likely to be hospitalized or die from heart failure. "Health professionals may need to improve current practices to better treat anemia in patients with chronic heart failure," says Dr. Lexin Wang, M.D., Ph.D., Head of the Cardiovascular Group at Charles Sturt University and co-author of the study. Even with contemporary medical treatment, the mortality rate from chronic heart failure is still very high, reaching 40 percent in very sick patients. Given the clear association between anemia and the mortality rate and hospitalization rate, optimal treatment of anemia, on top of other heart-failure-specific therapies, may reduce the rate of mortality and further improve patient"s prognosis. Co-Editor"s in Chief, Drs. John Strobeck and Marc Silver are feel that "this publication by Dr. Wang and collaborators give some perspective to nearly a decade of interest on the relationship and role of anemia in patients with chronic heart failure. To view the abstract for this article, please click here. Lexin Wang, M.D., Ph.D., is a professor of clinical pharmacology and Head of the Cardiovascular Group at Charles Sturt University. Sean Wagner Wiley-Blackwell


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