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Sleep Disturbances Influenced By Socioeconomic Status, Gender And Marital Status
According to a research abstract that will be presented on Wednesday, June 10, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, increased sleep disturbances are associated with lower education, income or being unmarried or unemployed. Disturbances are much more likely in multiracial individuals.

Novo Nordisk Convenes Policy And Clinical Experts At Diabetes Media Summit
A distinguished panel of clinical and policy experts gathered by Novo Nordisk recently convened in Washington, D.C. to explore solutions to address the exponential growth of diabetes in America. The universal theme from the renowned speakers, including Larry Hausner, CEO of the American Diabetes Association (ADA), was that the cost of the disease to our nation, at $218 billion annually, is startling and the lag in patient motivation to take action to offset the disease is distressing. Without intervention at both a national and patient level, our nation runs the risk of reaching a projected 50 million Americans having diabetes by the year 2025.
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Link Between Common Antibacterial Treatment And Sensorineural Hearing Loss In Cystic Fibrosis Patients
An otherwise effective treatment for cystic fibrosis places patients at a high risk of sensorineural hearing loss, according to new research published in the July edition of Otolaryngology-Head and Neck Surgery.
Medical Devices

Human Gastric Cancer: A Potent And Selective Anti-Tumor Agent

A research article published in the World Journal of Gastroenterology refers. The research team led by Professor Yan Li from Shengjing Hospital of China Medical University studied the growth inhibitory effects of Alisol B acetat and determined its mechanism of antitumor activity in human gastric cancer cell line SGC7901. Professor Li and his colleagues found that Alisol B acetat could inhibit the proliferation of SGC7901 cell in a time and dose dependent manner. Among the various phases of cell cycle, the percentage of cells in S phase was significantly decreased, while the percentage of cells in G1 phase was increased. Flow cytometry assay also showed Alisol B acetate had positive effect on apoptosis. Typical apoptotic morphology such as condensation and fragmentation of nuclei and formation of apoptotic bodies could be observed through electron microscope and phase-contrast microscope. Further investigating the molecular mechanism behind Alisol B acetat -induced apoptosis, cells treated with Alisol B acetat underwent a rapid loss of mitochondrial transmembrane potential, activition of caspase-3, -9, upregulation of Apaf-1 and Bax, and inhibition of the PI3K/Akt in a time-dependent manner. The researches domenstrated for the first time that Alisol B acetate induced human gastric cancer apoptosis through regulation of mitochondrial and PI3K/AKT signaling pathways Their research results indicate that Alisol B acetate might be used to treat gastric cancer , one of the most common cancers worldwide. By knowing the mechanism of action of Alisol B acetate, it may provide a new therapeutic option, as a potential anticancer agent, in the treatment of gastric cancer. Reference: Xu YH, Zhao LJ, Li Y. Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways. World J Gastroenterol 2009; 15(23): 2870-2877 http://www.wjgnet.com/1007-9327/15/2870.asp Correspondence to: Yan Li, Professor, Department of Digestive Diseases, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province,China. Lin Tian World Journal of Gastroenterology


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