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PerkinElmer Introduces Infrared Sensing And Photon Detection Solutions For Critical Environmental And Human Health Applications
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In today"s health environment, harmful cold and flu strains can travel the globe and pose serious risk to young children. And, at the same time, the FDA has issued warnings about administering over-the-counter cough and cold medications to children under the age of four. Parents of young children are in a quandary as to how to keep their kids safe and healthy. Many are embracing preventative measures to improve their child"s immune system and ward off illness.
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Could Standard Treatment For Traumatic Brain Injury Be Wrong?
Traumatic brain injury not heart disease, stroke or cancer is the number one cause of death and disability in people under 45. Each year, some 1.5 million Americans, including soldiers, athletes, the elderly and children, sustain head injuries, and nearly half of them will be hospitalized and treated in an emergency room or intensive care unit.
Public Health

Maternally Inherited Neurological Disorder In Golden Retriever Dogs Is Caused By A Mutation In Mitochondrial DNA

Sensory ataxic neuropathy (SAN) is a recently identified neurological disorder in Golden Retriever dogs with onset during puppyhood. Affected dogs move in an uncoordinated manner and have sensory deficits. Researchers from the Swedish University of Agricultural Sciences, Uppsala University and the Karolinska Institutet have now revealed that SAN is caused by a mutation in mitochondrial DNA. The study is published May 29 in the open-access journal PLoS Genetics. The researchers were able to trace back all affected offspring on the maternal side, over more than 10 generations, to a female that lived during the 1970s. This implied a maternal inheritance, which was confirmed by the identification of a one base pair deletion in the mitochondrial tRNA-Tyr gene. Further analyses revealed that the mutation leads to mitochondrial dysfunction, which in turn causes a progressive loss of neurons. The researchers showed that about five percent of the current Swedish Golden Retriever population carries the mutation causing SAN. The identification of the mutation now allows genetic screening tests to identify carriers and prevent the mutation being transmitted to further generations. "This is a good example of how a close collaboration between clinicians and geneticists led to a rapid detection of a harmful mutation that can now be eliminated from this dog population to reduce suffering and disease," said co-author Karin Hultin Jē¤derlund. The study also provides a new animal model for similar mitochondrial disorders in humans, said co-author Izabella Baranowska, and could potentially be used for testing therapeutic approaches. CITATION: "Sensory Ataxic Neuropathy in Golden Retriever Dogs Is Caused by a Deletion in the Mitochondrial tRNATyr Gene." Baranowska I, Jē¤derlund KH, Nennesmo I, Holmqvist E, Heidrich N, et al. (2009) PLoS Genet 5(5): e1000499. doi:10.1371/journal.pgen.1000499 Plos Genetics


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