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Popular Articles

Erectile Dysfunction Might Be Associated With Chronic Periodontal Disease: Two Ends Of The Cardiovascular Spectrum
UroToday.com - Together with Drs. Heruti, Bechor, Justo and Galor, we studied 815 Israeli male adults of whom 305 had complete data and were included in the statistical analysis. In the analyzed population, 2.1% of people without erectile dysfunction (ED) had advanced periodontal disease (defined as recession of periodontal bone of 6 mm or more) in comparison to 9.8% of the mild ED and 15.8% of the moderate/severe ED populations, respectively. However, due to the relatively small groups, we could not present the odds ratio. We are now planning a large-scale study to further establish the association between the two conditions.

Diabetes: It's Connection To Oral Health
According to the American Diabetes Association, nearly 24 million people have diabetes. Of that number, unfortunately, 5.7 million people are unaware that they have the disease. Diabetes can affect multiple parts of the body, including the kidneys, nerves, heart and even the mouth.
News of the day
UPMC Again Named To U.S. News & World Report Honor Roll Of America's Best Hospitals For The 10th Time
UPMC is once again the region"s only medical center named on the annual U.S. News & World Report Honor Roll of America"s Best Hospitals. UPMC is ranked 13th of only 21 hospitals nationwide who made the Honor Roll of the "nation"s best" in the 2009 survey.
Nutrition

Normal Development Of Cells With Abnormal Numbers Of Nuclei

Most of our cells contain a single nucleus that harbors 46 chromosomes (DNA and protein complexes that contain our genes). However, during normal postnatal development, liver cells containing two nuclei, each of which have 46 chromosomes, appear. These cells, which are known as binucleated tetraploid hepatocytes, arise in all mammals as a result of failure of the cellular process cytokinesis (the process by which the bulk of a cell, excluding the nucleus, divides to form two "daughter" cells). New insight into the failure of this process has now been provided by Chantal Desdouets and colleagues, at Institut Cochin, France, who have identified a cellular signaling pathway that leads to cytokinesis failure and the formation of binucleated tetraploid hepatocytes in rodents. Initial analysis revealed that weaning triggered the initiation of cytokinesis failure and formation of binucleated tetraploid hepatocytes in rats. Follow up studies in mice and rats indicated that the aspect of the suckling-to-weaning transition that controls the initiation of cytokinesis failure is the increase in insulin levels that occurs upon weaning. Further in vitro analysis, using pharmacological inhibitors, determined the signaling pathway by which insulin controlled cytokinesis failure. Future studies will investigate whether the deregulation of the insulin signaling pathway observed in various metabolic diseases alters the number of binucleated tetraploid hepatocytes in the liver ploidy profile and whether this has a role in disease. TITLE: The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents AUTHOR: Chantal Desdouets Institut Cochin, Universitç© Paris Descartes, Paris, France. View the PDF of this article at: https://www.the-jci.org/article.php?id=38677 Karen Honey Journal of Clinical Investigation JCI online early table of contents: June 15, 2009


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