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AstraZeneca Submits New Drug Applications For ZACTIMA(TM) In Second-Line Advanced Non-Small Cell Lung Cancer
AstraZeneca (NYSE: AZN) announced the company has submitted a New Drug Application to the U.S. Food and Drug Administration (FDA) and a Marketing Authorisation Application (MAA) to the European Medicines Agency (EMEA) for an investigational drug, vandetanib 100 mg for use in combination with chemotherapy for the treatment of advanced non-small cell lung cancer in patients previously treated with one prior anti-cancer therapy. The U.S. and European submissions are supported by data from Phase III clinical studies evaluating the safety and efficacy of vandetanib 100 mg in combination with chemotherapy. Pending approval, the treatment will be marketed as ZACTIMA(TM).

Somnia Anesthesia: 3rd Study Confirms Anesthesia Improves Cancer Detection In Colonoscopies
More pre-cancerous polyps were found in colonoscopies performed with deep sedation primarily using Propofol than with milder sedation in which patients remained conscious, according to a recent study conducted by Katherine Hoda, M.D. of Oregon Health and Science University. This improvement in cancer detection will save lives and reduce the number of patients requiring surgery and chemotherapy.
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PEPFAR Funds Used To Encourage Swaziland Couples To Get Tested Together
CNN examines the success of an HIV testing campaign in Swaziland that urges couples to get tested together. "The nationwide initiative - funded by the United States government and implemented by global charity "Population Services International" (PSI) - is aimed at couples because tests can be useless if partners are not aware of the others" HIV status," CNN writes.
Mental Health

School Program Cuts Problem Behaviors In Fifth Graders In Half

A study by Oregon State University researchers suggests that school-based prevention programs begun in elementary school can significantly reduce problem behaviors in students. Fifth graders who previously participated in a comprehensive interactive school prevention program for one to four years were about half as likely to engage in substance abuse, violent behavior, or sexual activity as those who did not take part in the program. The study, supported by the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health, will appear in the August, 2009, print issue of the American Journal of Public Health. The online version of the article is viewable today. "This study provides compelling evidence that intervening with young children is a promising approach to preventing drug use and other problem behaviors," said NIDA Director Nora Volkow. "The fact that an intervention beginning in the first grade produced a significant effect on children"s behavior in the fifth grade strengthens the case for initiating prevention programs in elementary school, before most children have begun to engage in problem behaviors." The study was conducted in 20 public elementary schools in Hawaii. Participating schools had below-average standardized test scores and diverse student populations with an average of 55 percent of students receiving free or reduced-price lunches. The intervention tested was Positive Action (PA), a comprehensive K-12 social and emotional development program for enhancing behavior and academic achievement. Schools were randomly assigned from matched pairs to implement PA or not. The program consists of daily 15-20 minute interactive lessons focusing on such topics as responsible self-management, getting along with others, and self-improvement. At schools implementing the intervention, these lessons occupied a total of about one hour a week beginning in the first or second grade. In fifth grade, 976 students (most aged 10 or 11) responded to a written questionnaire that asked about their use of substances, including tobacco, alcohol, and illicit drugs; involvement in violent behaviors, such as carrying a knife or threatening someone; and voluntary sexual activity. The total number of students reporting that they had engaged in any of these behaviors was small. Strikingly, however, students exposed to the PA program were about half as likely to report engaging in any of these behaviors as students not exposed to PA. Among students who were exposed to PA, those who had received the lessons for three or more years reported the lowest rates of experience with any of these problem behaviors. "This study demonstrates that a comprehensive, school wide social and character development program can have a substantial impact on reducing problem behaviors of public health importance in elementary-school-age youth," said Brian Flay, professor of public health at OSU and the study"s principal investigator. PA is an interactive program that integrates teacher/student contact and opportunities for the exchange of ideas as well as feedback and constructive criticism. The program is school wide and involves teachers and parents as well as students. It takes a positive, holistic approach to social and emotional development rather than focusing on the negative aspects of engaging in substance abuse and violence. Finally, at one hour a week, students" exposure to the program was intensive. "These features likely account for the large effect observed," said Flay. Flay plans to conduct a follow-up study to determine whether the beneficial effects of the PA program on fifth graders are sustained as the children grow older. OSU researchers Michael W. Beets, Samuel Vuchinich, Frank Snyder, Kin-Kit Li, Kate Burns and Isaac J. Washburn contributed to the study, along with Joseph Durlak from Loyola University. Brian Flay Oregon State University


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