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Sensitivity To NNKOAc Is Associated With Renal Cancer Risk
UroToday.com - Cigarette smoking is a major risk factor for renal cell carcinoma (RCC). Cigarette smoke contains a variety of carcinogenic chemicals such as polycyclic aromatic hydrocarbons, aromatic amines, heterocyclic aromatic amines and N-nitrosamines. Among the N-nitrosamines present in cigarette smoke, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and the most potent in terms of carcinogenicity.

Thousands Of Older People Dying Prematurely From Cancer, Say Researchers
As many as 15,000 people over 75 could be dying prematurely from cancer each year in the UK, according to research presented today at the National Cancer Intelligience Network (NCIN) conference.
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Sotomayor Nomination Raises Questions About How Female Judges View Cases Differently
Following President Obama"s nomination of Judge Sonia Sotomayor to replace retiring Supreme Court Justice David Souter, the differences between how male and female judges see and rule on cases has come into question, the New York Times reports. Although retired Supreme Court Justice Sandra Day O"Connor, the first woman to serve on the Supreme Court, often said that a female judge would come to the same decision as a male judge, Justice Ruth Bader Ginsburg has said that her perspective on certain cases is different because of her gender.The Times cites two examples, one involving the strip search of a 13-year-old girl -- to which Ginsburg said that her male colleagues could not understand how the girl felt. The second example involves the issue of certain abortion procedures. When deciding about the constitutionality of a federal ban on so-called "partial-birth" abortions, Ginsburg took issue with Justice Anthony Kennedy"s majority opinion that women who undergo the procedure likely would experience attacks of conscience. She responded that Kennedy"s views reflected "ancient notions of women"s place in the family and under the Constitution -- ideas that have long since been discredited."The issue has come up again with Sotomayor"s nomination, specifically regarding her 2001 statement that she "would hope that a wise Latina woman with the richness of her experiences would more often than not reach a better conclusion than a white male who hasn"t lived that life." The perception that female judges inherently might view cases differently than male judges has raised some concerns even among some female judges who believe it might be true, according to the Times. Judge Judith Kaye, former chief judge of New York state, said that she avoided discussing the issue with others but then accepted the idea that female judges see things differently at times. "To defend the idea that women come out different on some cases, I just feel it," Kaye said, adding, "I feel it to the depths of my soul" because women"s experiences are "just different." Attorney Lawrence Robbins, however, said, "Any person in the real world should be highly reluctant to make these broad generalizations."The most recent study comparing male and female judges found that female judges were more likely to rule in favor of plaintiffs who claim sex discrimination at workplaces. The study also found no differences in cases involving disability law, environmental issues and capital punishment (Lewis, New York Times, 6/3).
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Scientists Map Genome For Parasite Causing Widespread Infections

Scientists at the Southwest Foundation for Biomedical Research (SFBR) in San Antonio have for the first time constructed a genetic map of the parasite that causes schistosomiasis, a chronic intestinal infection that can damage internal organs and, in children, impair growth and cognitive development. Schistosome parasites are flatworms that infect more than 200 million people a year worldwide. Infection results in an estimated 200,000 deaths annually in sub-Saharan Africa alone, while 20 million suffer severe disease, according to the World Health Organization. "A genetic map is the essential tool needed for finding the genes that are responsible for drug resistance and pathogenesis in this parasite. In the case of drug resistance, identification of underlying mutations is critical for management of this disease" said Timothy Anderson, Ph.D., of SFBR"s department of genetics. "First, identification of mutations allows us to better understand the mechanism of action of the drugs used, and to redesign drugs to restore treatment efficacy. Second, identification of mutations involved allows us to efficiently monitor the spread of resistance in parasite populations using simple molecular methods." The new study was published in the June 30, 2009 issue of the journal Genome Biology, and was supported by the National Institutes of Health. Anderson, Charles Criscione, formerly of SFBR and now at Texas A&M University in College Station, and Phil LoVerde, now at the University of Texas Health Science Center in San Antonio used two adult flatworms to breed 88 S. mansoni offspring. By comparing the genetic information of the offspring to the parents, they generated a genetic map of chromosomes of the pathogen. Key contributers to the study included Claudia Valentim of SFBR and UTHSCSA and Hirohisa Hirai of Kyoto University in Japan. These parasites have a complex lifecycle. Adult male and female worms measuring around half an inch, live in pairs in the blood vessels, and eggs are expelled in the feces or urine. The larval parasites initially develop in water snails and human infection occurs when parasite larvae burrow through the skin of people entering the water. There are an estimated 400,000 imported cases in mainland USA. These parasites are an increasing public health threat in developing countries as a consequence of large scale dam construction projects. The researchers are planning further research using the genetic map to understand why some parasites cause more pathology than others. Southwest Foundation for Biomedical Research


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