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Tumor Metabolism Discovery Opens New Detection And Treatment Options For Rare Form Of Colon Cancer
People who suffer from Peutz-Jeghers syndrome, a rare inherited cancer syndrome, develop gastrointestinal polyps and are predisposed to colon cancer and other tumor types. Carefully tracing the cellular chain-of-command that links nutrient intake to cell growth (and which is interrupted in Peutz-Jeghers syndrome), allowed researchers at the Salk Institute for Biological Studies to exploit the tumors" weak spot.

Global Post Articles Examine Malaria Worldwide
Global Post examines the quest for an effective vaccine to fight malaria. According to Global Post, "epidemiologists are pinning their hopes on a malaria vaccine" because "[k]illing mosquitoes, or avoiding bites, is an imprecise solution to malaria."
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BSD Receives FDA Humanitarian Use Designation For The BSD-2000 Hyperthermia System
BSD Medical Corporation (NASDAQ:BSDM) announced that the U.S. Food and Drug Administration (FDA) has granted Humanitarian Use Device (HUD) designation for the company"s BSD-2000 Hyperthermia System for use in conjunction with radiation therapy for the treatment of cervical carcinoma patients who are ineligible for chemotherapy. This is the first of the two steps required to obtain Humanitarian Device Exemption (HDE) marketing approval, which requires BSD Medical to demonstrate the device"s safety and probable benefit in treating a disease or condition that affects fewer than 4,000 individuals in the United States per year. Now that FDA has granted the Humanitarian Use Designation for the BSD-2000, which confirms that the intended use population is fewer than 4,000 patients per year, BSD can file an HDE submission with the FDA. FDA has 75 days from the date of receipt of the HDE submission to grant or deny an HDE application. This period includes a 30-day filing period during which FDA determines whether the HDE application is sufficiently complete to permit substantive review. During this review, FDA may refine the indications for use which received HUD designation to finalize the indications for use for which HDE approval will be granted. This decision will be based on the data that are available to support the device"s HDE application. The company believes that the data previously submitted to FDA and reviewed by the agency in the company"s pending PMA application can be used to support the HDE approval, and that this previous review may expedite marketing approval for the BSD-2000.
Public Health

Sexual Crimes: Narrow Window For Detection Of Knock-Out Drugs

Drug-facilitated sexual crimes are increasing. The Bonn Institute for Forensic Medicine has recorded that the number of examinations on the use of intoxicants in sexual offences within their catchment area increased 10-fold between 1997 and 2006. In the current edition of Deutsches Arzteblatt International, Burkhard Madea and Frank Musshoff present the modes of action and the detection windows for the most frequent substances (Dtsch Arztebl Int 2009; 106 (20): 341-347). Many substances can be used as knock-out drugs, for example alcohol and liquid ecstasy. However, the most important are benzodiazepines and other hypnotics, which can act within 10 minutes. The victims report disturbed perception, a dazed feeling, nausea, disinhibition and lack of willpower. This was often followed by loss of consciousness for several hours, so that the victim could not remember the incident. It is often difficult to detect knock-out drugs, as they are rapidly broken down by the body. Benzodiazepines can be detected in the blood for a maximum of 24 hours and liquid ecstasy for only 8 hours. For this reason, if the administration of knock-out drugs is suspected, 100 mL urine and at least 10 mL blood should be taken as quickly as possible. If the interval between the incident and the medical examination is longer, a hair sample should be taken. This can be done up to 4 weeks after the incident. Involuntarily taken drugs are only detected in routine testing after 2% of offences. http://www.aerzteblatt.d Elke Bartholomç¤us M.A. Deutsches Aerzteblatt International e/v4/archiv/pdf.asp?id=64721


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