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Popular Articles

Possible Treatment For Spinal Muscular Atrophy
Spinal Muscular Atrophy is the second-leading cause of infant mortality in the world.

Latin America Must Cut Blood Pressure To Thrive
Combating high blood pressure is a global challenge. But while developed countries have enjoyed reductions in cardiovascular disease over recent decades, Latin America has been less fortunate. In fact new research published in the journal Therapeutic Advances in Cardiovascular Disease shows that high blood pressure is on the increase in many Latin American countries, a situation set to worsen unless immediate action is taken.
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AXURA(R)/AKATINOL(R) Enhances Communication Abilities In Patients With Alzheimer÷´s Disease - for A Longer Integration In Social And Family Life
Memantine improves functional communication skills in patients with moderate to severe Alzheimer"s disease (AD), noticeable by caregivers. These are the study results discussed at the International Conference on Alzheimer"s Disease (ICAD). The data of two recent clinical trials support that AXURA®/AKATINOL® - an uncompetitive NMDA receptor antagonist - effects language skills in AD patients and improves cognitive abilities and functional communication. Leading neurologists emphasize that improvement of communication skills is a meaningful treatment target. Communication breakdown can trigger feelings of frustration in Alzheimer"s patients and these feelings may manifest as behavioral instability. This in turn is known to be a major of caregiver"s burden and distress.
Mental Health

Stromal Marker For Breast Cancer Progression Identified

Dr. Arne Ostman and colleagues at the Karolinska Institutet in Stockholm have identified a stromal marker for breast cancer progression. They present these findings in the July 2009 issue of the American Journal of Pathology. Platelet-derived growth factor (PDGF) receptors are involved in multiple stages of cancer cell growth. However, the contribution of PDGFR expression in the stroma, or surrounding supportive tissue, of the tumor remains unclear. Paulsson et al therefore characterized PDGFR expression in stroma of various tumors, including lymphoma and colon, ovarian, prostate, lung, and breast cancer. They found highly variable PDGFR expression in solid tumors, with colon and prostate tumors expressing the highest stromal levels of one type of PDGFR, PDGFí²R. In breast cancer, stromal PDGFí²R expression in pre-menopausal breast cancer patients significantly correlated with negative prognosis. These data highlight the importance of examining stromal as well as malignant cell expression of PDGF receptors in disease prognosis. Paulsson et al suggest that "the findings in the present study of robust staining procedures for PDGF receptors should motivate continued studies of the response-predicative value of stromal PDGF receptor status." Paulsson J, Sjö¶blom T, Micke P, Pontö©n F, Landberg G, Heldin C-H, Bergh J, Brennan DJ, Jirströ¶m K, ö-stman A: Prognostic significance of stromal PDGF í²-receptor expression in human breast cancer. Am J Pathol 2009, 174: 2752-2764 Angela Colmone American Journal of Pathology


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