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Lilly Resubmits Cymbalta(R) Supplemental New Drug Application For Chronic Pain To U.S. Food And Drug Administration
As projected, Eli Lilly and Company (NYSE: LLY) has resubmitted its supplemental New Drug Application (sNDA) for Cymbalta(R) (duloxetine HCl) for the management of chronic pain to the U.S. Food and Drug Administration (FDA). Lilly"s resubmission is based on a recently completed study in chronic pain due to osteoarthritis, the extension phase of a chronic low back pain study and previously completed studies in pain due to osteoarthritis and chronic low back pain. The application is supported by studies in diabetic peripheral neuropathic pain (DPNP) and fibromyalgia.

Online Obituaries Are Changing The Way We Publicly Remember The Dead And How Newspapers Cover Deaths
The ways we deal with death are finding a new life online, according to research being published by a Kansas State University journalism professor and her colleague.
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Diabetes: It's Connection To Oral Health
According to the American Diabetes Association, nearly 24 million people have diabetes. Of that number, unfortunately, 5.7 million people are unaware that they have the disease. Diabetes can affect multiple parts of the body, including the kidneys, nerves, heart and even the mouth.
Mental Health

Trapping Immune Cells In The Uterus Prevents Anti-fetal Immunity

Why the immune system of a pregnant woman does not attack her developing fetus is one of most remarkable features of pregnancy, and several underlying mechanisms have been described. However, Adrian Erlebacher and colleagues, at the New York University School of Medicine, New York, have now identified a new mechanism to explain why the mouse maternal immune system does not attack the fetuses. Once an embryo implants into the wall of the uterus, a cellular structure known as the decidua forms around the embryo and placenta. In the study, the formation of the decidua was found to prevent immune sentinel cells known as DCs from leaving the maternal/fetal interface and traveling to the local lymph nodes to activate an immune response toward the fetus. The authors therefore suggest that impaired formation or function of the human decidua might allow DCs to leave the decidua to initiate an aggressive immune response toward the fetus, something that might contribute to poor pregnancy outcomes. In an accompanying commentary, Bali Pulendran, at Emory Vaccine Center at Yerkes National Primate Research Center, Atlanta, discusses how this new research affects current thinking about avoiding immune surveillance at the maternal/fetal interface. TITLE: Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice AUTHOR CONTACT: Adrian Erlebacher New York University School of Medicine, New York, New York, USA. View the PDF of this article at: https://www.the-jci.org/article.php?id=38714 ACCOMPANYING COMMENTARY TITLE: Restraining order for dendritic cells: all quiet on the fetal front AUTHOR CONTACT: Bali Pulendran Emory Vaccine Center at Yerkes National Primate Research Center, Atlanta, Georgia, USA. View the PDF of this article at: https://www.the-jci.org/article.php?id=39946 Karen Honey Journal of Clinical Investigation


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