Sexual Health
Patients can expect significant savings and better outcomes from their prescription medications when health care professionals use comparative effectiveness research, according to researchers at the University of Illinois at Chicago.
The Heatwave Plan has been updated to advise those suffering breathing problems that although ozone levels increase in hot weather, they drop in the evening. People with respiratory problems should stay inside during the hottest part of the day and windows should be kept shaded and closed when the temperature is hotter outside than inside.
In studying the preventive effects of vitamin D, researchers at the Moores Cancer Center at the University of California, San Diego, have proposed a new model of cancer development that hinges on a loss of cancer cells" ability to stick together. The model, dubbed DINOMIT, differs substantially from the current model of cancer development, which suggests genetic mutations as the earliest driving forces behind cancer.
Private Healthcare UK - the UK"s leading web portal for information on private treatment and private healthcare services and providers is now available on NetDoctor.co.uk.
The Senate Health, Education, Labor and Pensions Committee on Wednesday voted 15-8 to approve a bill (S 982) giving FDA authority to regulate tobacco products, the Wall Street Journal reports. Under the bill, FDA could ban certain tobacco products, such as candy-flavored cigarettes, restrict tobacco advertising to black-and-white ads, and prohibit use of the terms "mild" and "low tar" (Yoest/Mundy, Wall Street Journal, 5/21). FDA also could limit the amount of nicotine in tobacco products, as well as enlarge warning labels. To pay for the new regulatory efforts, the bill would require all tobacco companies to pay a fee that would raise nearly $5.4 billion over the first 10 years. Committee members voted down a number of amendments:
The number of people who each year die or are severely disabled by stroke could be substantially reduced through a cheap blood test and simple inexpensive treatment.
Standard Chartered"s Group Finance Director, Richard Meddings, has pledged to run The Standard Chartered Great City Race 2009 blindfolded to help raise funds for the race"s official community partner, Seeing is Believing (SiB). Today, organisers call for the other runners to start fundraising and help make a difference*.
Yolo County, Calif., Board of Supervisors on Tuesday approved a proposal to cut county funding for health care services for undocumented immigrants in an effort to save the county more than $1 million, the Sacramento Bee reports (Sangree, Sacramento Bee, 5/20).California counties have been taking such action amid the economic recession to reduce their budgets. In February, Sacramento County voted to prohibit undocumented immigrants from receiving care at county clinics to save an estimated $2.4 million. Contra Costa County last month cut services for undocumented adults, seeking to save an estimated $6 million. Yolo County is facing a $24 million budget deficit for fiscal year 2009-2010 (Kaiser Health Disparities Report, 5/7).Robin Affrime -- head of CommuniCare Health Centers, which provide treatment to low-income residents of Woodland, Davis and West Sacramento -- said the county spending cuts would shift costs to health care providers. Supervisor Jim Provenza said undocumented immigrants would delay care at clinics and eventually seek treatment in hospital emergency departments (Sacramento Bee, 5/20).
BioAlliance Pharma SA (Paris:BIO), a company dedicated to therapies and supportive care for cancer and AIDS patients, announced its scientific communications at upcoming international conferences on infectious diseases and oncology:
"Stem cell research and regenerative medicine are in an extremely exciting phase right now. We are gaining knowledge very fast and many companies are being formed and are starting clinical trials in different areas," says Dr Jonas Frisç©n.
Inuit children have the highest rate of hospital admission for Lower respiratory tract infections (LRTIs) globally, but new research shows that lowering risk factors though public health interventions and an enhanced immunization program could improve health for Inuit children and lower health care costs significantly. The first-of-its-kind case control research was conducted by Dr. Anna Banerji, a pediatric infectious disease specialist and researcher at St. Michael"s Hospital.
This is a personal account of my battle so far with prostate cancer. My name is Christian Nordqvist, 53, Editor of Medical News Today. On 26th of March, 2009, I underwent a radical prostatectomy - in other words, I had my prostate taken out. A biopsy had detected cancerous tissue in the prostate. Before that, a routine check-up had revealed higher than normal levels of PSA in my blood. After discussing various options with my urologist, we decided that radical prostatectomy was best for me. There were two compelling reasons for this - I am 53 (relatively young for this type of disease), and I have a family history of prostate cancer.
Agios Pharmaceuticals, the first biopharmaceutical company focused on discovering and developing novel cancer metabolism drugs, announced that the leading scientific journal Science has published a review article, "Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation," authored by two of its founders, Lewis C. Cantley, Ph.D., Director of the Cancer Center at Beth Israel Deaconess Medical Center and Professor of Systems Biology and Craig B. Thompson, M.D., Director, Abramson Cancer Center, University of Pennsylvania, and one of its scientific advisors, Matthew Vander Heiden, M.D., Ph.D., Instructor of Medicine, Dana Farber Cancer Institute and Harvard Medical School.
People with diabetes who maintain intensive, low blood sugar levels are significantly less likely to suffer heart attacks and coronary heart disease, new research published in The Lancet has shown.
The widely-used Affymetrix Whole-Transcript Gene 1.0 ST (sense target) microarray platform, normally used to assay gene expression, can also be utilized to interrogate exon-specific splicing. Research published in the open access journal BMC Bioinformatics shows scientists how to monitor alternative splicing activity on a genome-wide scale, without investing in new exon microarray technologies.
New research provides exciting genetic insight into a rare syndrome that first appeared in the medical literature in the mid 1800s with the case of Julia Pastrana, the world"s most notorious bearded lady. The study, published by Cell Press in the May 21st issue of the American Journal of Human Genetics, reveals intriguing molecular clues about the pathogenesis of this mysterious condition that has captured the attention of the public since the Middle Ages.
Molecular superfamily causes melanoma spread A superfamily of molecules holds the secret to the development and spread of melanoma - the deadliest form of skin cancer, revealed a study published in the British Journal of Cancer*.
Interfacing neurons with micro- and nano-electronic devices has been a subject of intense studies over the last decade and is used both in basic research and medical applications. The electronic devices used in such neuroelectronic hybrids are mainly planar metal electrodes and planar transistors.
A meta-analysis of five trials has shown that more intensive glucose control in type 2 diabetes leads to fewer heart attacks and heart disease events - but has no significant effect on stroke or mortality from all causes. The findings are reported in an Article in this week"s diabetes special issue of The Lancet, written by Dr Kausik Ray, University of Cambridge, UK, and colleagues.
The winners of the American Psychiatric Association"s (APA) prestigious "Young Minds in Psychiatry" awards were announced today at the APA"s 162nd Annual Meeting in San Francisco, CA. For the first time, researchers from Nigeria and India have been selected to receive awards, recognizing the exceptional challenges faced by researchers in developing countries.
Genomic Health, Inc. (Nasdaq: GHDX) announced positive results from the landmark QUASAR validation study, which demonstrated that the Oncotype DX(R) colon cancer test can independently predict individual recurrence risk in stage II colon cancer patients following surgery. Importantly, the Oncotype DX colon cancer Recurrence Score(R) provided additional independent clinical value beyond standard measures. The study showed that the colon cancer Recurrence Score maintained significance (p=0.008), independent of mismatch repair (MMR), also known as MSI (Microsatellite Instability), T-stage, nodes examined, grade and lymphovascular invasion.
Biovest International, Inc. (Other OTC:BVTI), a majority-owned subsidiary of Accentia Biopharmaceuticals, Inc. (Other OTC:ABPIQ), announced that BiovaxID®, Biovest"s personalized anti-cancer vaccine targeting B-cell blood cancers, will be featured in an oral presentation during the Plenary Session at the American Society of Clinical Oncology (ASCO) Annual Meeting on Sunday, May 31st, 2009 in Orlando, Florida.
Seattle Genetics, Inc. (Nasdaq:SGEN) announced that data from a phase I clinical trial evaluating every three week dosing of SGN-35 and a phase I clinical trial of lintuzumab (SGN-33) will be reported at the 14th Congress of the European Hematology Association (EHA) being held June 4-7, 2009 in Berlin, Germany. The abstracts are available from the EHA website at http://www.ehaweb.org.
PharmAthene, Inc. (NYSE Amex: PIP), a biodefense company developing medical countermeasures against biological and chemical threats, announced that the Company has submitted its comprehensive regulatory strategy to the U.S. Food and Drug Administration (FDA) outlining the non-clinical and clinical development plans for licensure of SparVax(TM), a next generation recombinant protective antigen anthrax vaccine.
As a Dallas-based physician, there has been a recent flurry of panic about the H1N1 (swine influenza). School districts closed down. Intramural sports statewide were cancelled. Some even suggested closing the border with Mexico, where approximately three quarters of a million people routinely cross back and forth every day. The panic certainly was fueled by the media reports. Likewise, the media can serve to educate the public about health issues.
The number of MDCT examinations for suspected pulmonary emboli (PE) is rapidly increasing amongst ER patients, with a decrease in the number of positive studies. This may be due to a failure to adhere to established clinical guidelines for evaluating patients with suspected PE, according to a study performed at the Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI.
The following summarizes selected women"s health-related blog entries. ~ "Peaceful Revolution: Another Blow to Women," Debra Ness, Huffington Post blogs: The Supreme Court"s ruling this week in AT&T Corp. v. Hulteen "dealt a serious and painful blow to working women and the families who rely on their retirement benefits," Ness, president of the National Partnership for Women and Families, writes. The ruling "affects a limited number of people," and it "would be easy to ignore them -- easy, but terribly wrong," Ness continues. "This ruling sends a terrible message about whether discrimination will bring penalties and costs, and whether the courts will address the ongoing effects of prior discrimination," she writes. Ness notes that the ruling "couldn"t come at a worse time," adding, "In today"s grim economic climate, women and their families cannot afford to see their retirement benefits kept lower by discriminatory workplace policies that should have been remedied decades ago." Ness writes that it is "sobering that, at a time when negative stereotypes about pregnant women clearly persist, we have a Supreme Court that doesn"t stand firm for equal rights and equal opportunity." She concludes, "It"s a good reminder of what"s at stake with the Supreme Court nomination President Obama is about to make" (Ness, Huffington Post blogs, 5/21).~ "This Week in Religion and Politics," Sarah Posner, American Prospect"s "The FundamentaList": When "viewed in the context of Obama"s entire faith-based outreach project, the events" surrounding the University of Notre Dame"s commencement ceremony "highlighted how he has embraced traditionalist, conservative religion -- to the detriment of sexual and reproductive justice," Posner writes. President Obama has "focused his outreach efforts" to reduce the need for abortion "on more conservative religious groups" and "claims to honor their position on moral issues," Posner writes. However, "when the dust settles on the Notre Dame controversy, he"ll have to figure out what to do with the policy advice he has sought" from the White House Office on Faith-Based and Neighborhood Partnerships, she continues. Posner adds, "How Obama reacts to that advice will demonstrate whether the council is mere window dressing to shore up support from swing constituencies or whether Obama will yield to conservative religious dogma on reproductive-health issues." Meanwhile, Christian conservatives have been "making hay of the findings" of recent Pew and Gallup polls that found more U.S. residents identifying with "pro-life" positions and using the data to argue "that Obama"s position is out of touch with the majority of Americans," Posner writes. However, as bloggers at The Monkey Cage and FiveThirtyEight have pointed out, the polls are not representative of most U.S. residents" views on abortion rights, she writes. "Because of that deception on reproductive rights, it"s more important than ever for the president to lay the moral groundwork for his own position -- not just to recognize the moral qualms of abortion opponents," Posner says (Posner, "The FundamentaList," American Prospect, 5/20).~ "Meghan McCain Preaches What She Practices," Willa Paskin, Slate"s "XX Factor": Meghan McCain -- Sen. John McCain"s (R-Ariz.) daughter -- "acquitted herself quite admirably" on Monday"s episode of Comedy Central"s "The Colbert Report" by "defending her core position" that the Republican Party "needs to appeal to younger voters, and it can only do so by getting liberal on social issues," Paskin writes. On the show, McCain said, "I think it"s not realistic for this generation to be just plain abstinent, I think we need to have sex education with condoms and birth control. ... I would never practice anything I didn"t preach." Paskin also includes a video clip of McCain"s appearance (Paskin, "XX Factor," Slate, 5/19).~ "Skill the Messenger," Cristina Page, Birth Control Watch: Alaska Gov. Sarah Palin"s (R) 18-year-old daughter Bristol -- who was
Despite calamities from economic recessions, wars and famine to a flu epidemic afflicting the Earth, a new study from the University of Kansas and Gallup indicates that humans are by nature optimistic.
Boxer Evander Holyfield will fight Sammy Retta on July 26 in Ethiopia in an effort to raise money for HIV/AIDS organizations, Reuters India reports. Event organizers hope to raise between $5 million and $10 million from the fight. "I continue to strive to be the very best, but what got me to come here is" HIV/AIDS, Holyfield said, adding, "If we don"t find a cure to this, we"ll be extinct." According to Everton Boland -- CEO of Golden Globe, which is promoting the fight -- a significant portion of money raised will go directly to organizations addressing HIV/AIDS. Organizers said that a group established by African first ladies is the only recipient selected to date but they are considering others (Malone, Reuters India, 5/20).
Looking for efficient anti-tumor drugs is a hot research area. Chrysin (5,7-dihydroxy flavone), a natural widely-distributed flavonoid, has been reported to have many different biological activities such as anti-oxidant, anti-virus, antidiabetogenic activity and clear anxiolytic effect. However, Chrysin is limited in its clinical application because of its modest absorption in the intestine and rapid in vivo glycosylation. To improve the biological activity of chrysin, a number of its derivatives have been prepared for biological testing. 5-allyl-7-gen-difluoromethylenechrysin (ADFMChR) is one of them.
It appears that some superbugs have evolved to develop the ability to manipulate the immune system to everyone"s advantage.
The US Centers for Disease Control and Prevention (CDC) said that there is a "global need for more systemic surveillance of influenza viruses
Today, fifteen new research projects aimed at bringing innovative medicines to market faster have been selected to receive 246 million Euros from the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA), of which the Irish Pharmaceutical Healthcare Association (IPHA) is a member. The projects will foster understanding of health issues such as diabetes, pain, severe asthma and psychiatric disorders while increasing medicine safety. They will also help improve the training of researchers and clinicians involved in medicines development. The projects were chosen following the first call for proposals launched within the Innovative Medicines Initiative (IMI), a public-private partnership - so called Joint Technology Initiative - between the European Commission and the pharmaceutical industry.
The Premier healthcare alliance received the "Champion for Change" award from Practice Greenhealth (PGH) in recognition for leadership in advancing environmental best practices in healthcare. This marks the seventh consecutive year that Premier has been awarded this distinction.
Women who are at risk for heart disease and who are also experiencing menopause symptoms now have an added re - a highly specialized clinic in the Division of Cardiology at the Cedars-Sinai Heart Institute. The Advanced Preventive Women"s Clinic at the Women"s Heart Center recently opened and is offering comprehensive cardiac risk assessments designed specifically for women who are in menopause. The clinic also offers menopausal patients state-of-the-art screenings, as well as personalized medicine therapies and counseling, including high-risk hormone counseling.
A survey among Britain"s 40,000 sufferers from dystonia - a
Cancer Research UK scientists have tamed a virus so that it attacks and destroys cancer cells but does not harm healthy cells, according to a paper published in PLoS Pathogens*.
The number of people diagnosed with the deadliest form of skin cancer has crashed through the 10,000 barrier after an alarming rise in new cases, according to the latest Cancer Research UK figures revealed today.
Yesterday, a jury in the United States District Court for the District of Columbia found that the Federal Bureau of Investigation (FBI) discriminated against Jeff Kapche when it refused to hire him as a Special Agent because of his diabetes.
People with diabetes who were prescribed the cholesterol-lowering drug fenofibrate reduced their risk of minor amputations by 36 per cent, according to new research.
The GMC is proposing to extend the types of cases that can be concluded by "consensual disposal" instead of being referred to a full fitness to practise hearing.
The Keck School of Medicine of the University of Southern California (USC) today announced a $5 million gift from the Ellison Medical Foundation to support cancer research under the direction of David B. Agus, M.D., a renowned oncologist and cancer researcher who joined the Keck School faculty on April 1 as a professor of medicine.
As the nation debates health reform options, the Center for Health Care Strategies (CHCS) is launching Transforming Care for Dual Eligibles , a state initiative to test innovative care models for people who are dually eligible for Medicare and Medicaid ("dual eligibles"). Colorado, Maryland, Massachusetts, Michigan, Pennsylvania, Texas, and Vermont will implement strategies to improve care and control costs for dual eligibles, a high-need population with health care costs nearly five times those of other Medicare beneficiaries. The program is made possible through support from The Commonwealth Fund.
A new survey released by Royal Philips Electronics (AEX: PHI, NYSE: PHG) shows that the average manager is sleeping 19 percent less than the recommended amount of eight hours a night. The survey, conducted in five countries around the globe, showed that 40 percent of those questioned blame the state of the world economy as the major reason for their lack of sleep.
Diagnostic companies looking for growth in a tough economy can still find a vibrant market for their products in China, says a leading healthcare market research publisher. IVD markets in China will grow to more than $1.5 billion in 2009, making it the world"s sixth largest IVD market. The last few years have seen market growth of 15-20%. With about 575 new hospitals opening each year and a government plan to open more than 20,000 health clinics, the lab market is booming, according to a new report, "Who is Who in Clinical Diagnostics in China (Manufacturers and Distributors Profiles, Market, Industry Overview)," from Kalorama Information, in partnership with IVD market research firm McEvoy & Farmer.
QIAGEN announced the launch of a novel product for extraction of free circulating fragments of tumor- and fetal-derived nucleic acids as well as viral nucleic acids in human blood. Scientists consider these DNA and RNA fragments to have great potential for the highly sensitive and non-invasive diagnosis of a wide range of diseases, including congenital disorders, malignancies such as colon and lung cancer, and infections. The new QIAamp Circulating Nucleic Acid Kit is expected to significantly facilitate the corresponding biomarker research and the introduction of novel molecular tests in prenatal diagnostics which can replace risky, invasive procedures such as amniocentesis.
The primary objective of this workshop was to develop a comprehensive R&D roadmap that would fast-track the use of focused ultrasound technology to treat a variety of brain disorders including benign and malignant tumors, Parkinson"s disease and essential tremor, stroke, and epilepsy.
UroToday.com - Cigarette smoking is a major risk factor for renal cell carcinoma (RCC). Cigarette smoke contains a variety of carcinogenic chemicals such as polycyclic aromatic hydrocarbons, aromatic amines, heterocyclic aromatic amines and N-nitrosamines. Among the N-nitrosamines present in cigarette smoke, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and the most potent in terms of carcinogenicity.
The Pharmaceutical Marketing Society is pleased to announce the launch of an all new Digital Media Awards, to be held in October 2009 in London.
According to a new position statement from the National Athletic Trainers" Association (NATA), proper management of acute spinal injuries on the athletic playing field is crucial, given that sports participation constitutes the second most common cause of spinal cord injuries for Americans age 30 and younger. Sports medicine providers and others on the sidelines need to be familiar with the appropriate acute-management guidelines for athletes with cervical-spine injuries. Published in this month"s Journal of Athletic Training, NATA"s scientific publication, the position statement provides detailed guidelines for the immediate treatment and transport of athletes who are injured on the playing field.
Nigel Edwards, the director of policy at the NHS Confederation, said, "The surpluses generated by the NHS over the 2007-2008 financial year are a testament to sound financial planning and an awareness on the part of everyone in the service of the need to spend public money carefully.
New research presented at the annual meeting of ISPOR suggests that prescribing Aricept on diagnosis of either mild or moderate Alzheimer"s disease would save the NHS money.
The relationship between the dental disease periodontitis and coronary heart disease (CHD) has been known for several years. Although a genetic link seemed likely, until now its existence was uncertain. Now, for the first time, scientists have discovered a genetic relationship between the two conditions, a researcher told the annual conference of the European Society of Human Genetics.
At the 50th Annual Trumpet Awards Luncheon at the Palmer House Hilton in Chicago, Sandra R. Gordon received one of the most coveted public relations awards from the Publicity Club of Chicago (PCC). As the director of public relations at the American Academy of Orthopaedic Surgeons (AAOS), Sandra was the lead visionary and creative force for their organization"s multi-faceted special event "Seventy-five Years of Orthopaedic Surgery".
Children are a pain in the back!
World renowned virologist Professor Albert Osterhaus told participants at Europe"s largest conference on infectious diseases that the outbreak of influenza A H1N1 is without question the most important event of the past 40 years in human influenza. And he stressed that the current H1N1 threat is a serious one.
A family-based prevention program designed to help adolescents avoid substance use and other risky behavior proved especially effective for a group of young teens with a genetic risk factor contributing toward such behavior, according to a new study by researchers at the University of Georgia. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA), components of the National Institutes of Health, supported the study, which appears in the May/June issue of Child Development.
Researchers long ago rejected the theory that vaccines cause autism, yet
If we imagine our immune system to be a police force for our bodies, then previous work has suggested that the Lymph nodes would be the best candidate structures within the body to act as police stations - the regions in which the immune response is organised. However, a new paper - published in this week"s issue of PLoS Biology - suggests that lymph nodes are not essential in the mouse in marshalling T-cells (a main immune foot soldier) to respond to a breach of the skin barrier. This result is both surprising in itself, and suggests a novel function for the liver as an alternate site for T-cell activation.
Patients living with migraine have strong reason for new optimism concerning a positive future. Two review articles and an accompanying editorial, "The Future of Migraine: Beyond Just Another Pill," in the current issue of Mayo Clinic Proceedings, are the basis for an ironic premise.
A study led by researchers at Fred Hutchinson Cancer Research Center has identified two proteins in the blood that could become important prognostic markers for long-term survival in breast cancer patients. The proteins are associated with chronic inflammation, which is known to contribute to cancer development and progression.
Philadelphia"s Wistar Institute has been issued U.S. patent No. 7,527,798 for a synthetic vaccine technology with the potential to be developed into a universal flu vaccine that could eliminate annual flu shots and protect against pandemics. Wistar is seeking a corporate partner to license and develop the vaccine, which has been tested in animals and currently is in prototype form. The patent pertains to technology developed by Walter Gerhard, professor emeritus and former professor of immunology at Wistar, and Laszlo Otvos, formerly an associate professor of immunology at Wistar. The vaccine prototype contains an engineered peptide that mimics a viral coat protein called M2 that remains largely constant from year to year.
A new home test kit called SpermCheck Vasectomy, based on a protein discovered at the University of Virginia (UVA) Health System, marks the launch of a product line that could revolutionize the way men monitor their reproductive status. Based on antibodies that bind to SP-10, a protein discovered in the laboratory of John C. Herr, PhD, SpermCheck Vasectomy is the only FDA-approved immunodiagnostic test for monitoring sperm after vasectomy.
California (USC) have identified a
Supporters of embryonic stem cell research have expressed concern about the impact on existing research efforts under the Obama administration"s draft guidelines outlining criteria for federal funding of stem cell research, the Washington Post reports. The public comment period for the guidelines ends Tuesday and has generated more than 20,000 comments addressing nearly every element of the proposal. The guidelines, which NIH issued in April, propose limiting federal funding for the research to stem cells derived from unused embryos created for fertility treatments and willingly donated by patients who have given written consent. Former President George W. Bush in August 2001 enacted restrictions limiting federal funding for the research to the 21 stem cell lines existing at the time. Although President Obama in March signed an executive order lifting Bush"s restrictions, some proponents of embryonic stem cell research have suggested that Obama"s plan could actually jeopardize many existing research efforts. The Obama administration is expected to issue its final version of the guidelines by July 7, the Post reports.After Bush restricted federal funding to the embryonic stem cell lines already in existence, many researchers turned to private donors and state governments for the financial support to create hundreds of new lines. Although supporters of the research initially were pleased that the Obama administration"s guidelines would allow federal funding for research on these new existing lines, some are now concerned that certain stipulations in the new guidelines could actually disqualify these research efforts from receiving federal funding. For example, NIH"s proposal requires that couples who wish to donate unused embryos for research sign a consent form indicating that they were fully informed of their alternatives. Although many fertility clinics provide information for couples about their other options, few clinics note these details in written consent forms, according to the Post. Therefore, existing stem cell lines derived from embryos donated by couples who did not sign the required consent forms could be ineligible under NIH"s draft proposal, the Post reports. In addition, many stem cell research supporters also expressed disappointment that only unused embryos created for fertility treatments would be eligible for federal funding.George Daley of the Harvard Stem Cell Institute said that the Obama administration"s guidelines "take 2009 standards and attempt to apply them retroactively, which isn"t really a standard that would allow most of the pre-existing lines to be acceptable for NIH funding." Lawrence Goldstein, director of the University of California-San Diego"s stem cell program, said, "It"s not that past practices were shoddy. But they don"t necessarily meet every letter of the new guidelines moving forward." Goldstein added that researchers would "have to throw everything out and start all over again" under the new proposed guidelines. Amy Comstock Rick, CEO of the Coalition for the Advancement of Medical Research, said that her group is "very concerned" about the funding prospects for existing research efforts, adding that if NIH officials do not modify the guidelines, "very little current research would be eligible" to receive federal funds. However, Raynard Kington, acting NIH director, said the agency is aware of the concerns and "will take them into consideration." He added that "it"s unambiguous that the intent of the president was to expand opportunities and research in this area," as long as such research is "scientifically worthy" and "ethically responsible" (Stein, Washington Post, 5/25).
The Excellence in Oncology Awards (EinO) 2009 are now open for entry. The Awards, now in their fourth year, recognise and reward best practice in oncology management, education and patient care throughout the UK. Winners will be announced at a prestigious dinner on 6 October 2009 during the National Cancer Research Institute (NCRI) Cancer Conference.
Health officials recently held a regional consultation in Kenya to examine mother-to-child HIV transmission services and pediatric HIV/AIDS care in nine Eastern and Southern African countries, IRIN/PlusNews reports. The consultation -- hosted by UNICEF, UNAIDS and the World Health Organization -- included representatives from Ethiopia, Kenya, Malawi, Mozambique, South Africa, Swaziland, Tanzania, Uganda and Zambia. The meeting addressed issues in MTCT prevention services -- including the continued use of single-dose nevirapine instead of more effective combination therapies, as well as delays in diagnosing and initiating treatment -- that are weakening prevention programs in focus countries. According to IRIN/PlusNews, 70% of pregnant women in Eastern and Southern African countries are seen by a health care provider at least once during pregnancy. However, 43% of HIV-positive pregnant women have a health care worker present during labor who can administer PMTCT treatment. In Uganda, a national policy calls for all sub-county level health facilities to provide PMTCT services, but only 53% offer such services because of health worker shortages. Janet Kayita, regional PMTCT adviser for UNICEF, said, "We are doing a bad job of testing women for HIV and then following them up, and an even worse job of ensuring that infants receive appropriate prevention and treatment services." She added that national PMTCT guidelines have not reached local levels. "These policies must become a reality for the people they were designed to help," Kayita said, adding that primary health care systems at all levels must be strengthened (IRIN/PlusNews, 5/25).Some officials at the meeting called on African governments to reach 80% of pregnant women, mothers and children with services; reduce by 50% the number of women and infants who do not receive follow-up care; and double the number of HIV-positive children who receive antiretroviral treatment. Xinhuanet reports that prevention services currently reach about 50% of pregnant women in all Eastern and Southern African countries. At the close of the consultation, officials issued a set of recommendations for meeting PMTCT goals, including increased community involvement in prevention programs; reduced workloads for health workers; and increased coverage of and compliance with PMTCT regimens. In addition, the experts urged governments to prioritize regions with high HIV burdens and strengthen data management to better understand trends (Ooko, Xinhuanet, 5/25). James Kamau, coordinator of the Kenya Treatment Access Movement, recommended that more women in the country deliver in hospitals in order to ensure that they receive PMTCT services (Mwaniki, Daily Nation, 5/25). David Alnwick, a UNICEF regional adviser, said, "It is critical at this juncture, when many countries are faced with shrinking budgets and competing demands, that we do not lose the momentum of what needs to be done to create an AIDS-free generation" (Xinhuanet, 5/25).
Despite being larger in size and heavier in weight, an analysis of the cardiovascular disease risk factors of about 500 National Football League players finds that overall, they have a similar cardiovascular risk profile compared to the general population. The NFL population was found to have a lower incidence of impaired fasting glucose and similar prevalence of abnormal cholesterol and triglyceride levels as compared to a sample of healthy young-adult men, but have an increased prevalence of high blood pressure, according to a study in the May 27 issue of JAMA.
Coconino County Health Department (CCHD) officials announced today the first case of H1N1 (swine) flu in Coconino County. The Arizona Department of Health Services Lab confirmed that a 24 year-old male from the Navajo Nation has tested positive for the illness. The man went to the Tuba City Regional Health Care Corporation Emergency Department with flu-like symptoms and was tested. He is now recovering from the illness.
Mountain climbers and adventurers who aspire to ascent Mount Everest have more information on immune function and the onset of acute mountain sickness (AMS), thanks to research presented today at the 56th Annual Meeting of the American College of Sports Medicine in Seattle. A team of medical students climbed to Everest Base Camp in order to find physical factors that would reveal information about illness severity in association with immune and hormonal responses to high-altitude exposure.
A group of cancer patients, genetic researchers and professional pathologist organizations has filed a lawsuit against Myriad Genetics and the U.S. Patent Office over the patent of two genes associated with an increased risk of breast and ovarian cancers, the New York Times reports. According to the Times, the government more than 10 years ago granted Myriad the patent on the BRCA1 and BRCA2 genes, as well as the company"s genetic test that measures a patient"s risk for the cancers.The lawsuit was filed by the American Civil Liberties Union and is believed to be the first of its kind, the Times reports. The lawsuit challenges the decision to grant patents on genes to Myriad and companies like it. The plaintiffs say that patents on genes restrict medical and research efforts, while companies like Myriad have said that the patent system supports innovation by giving them a temporary monopoly after they make a discovery, thereby rewarding prior investment in research and development.Wendy Chung, the director of clinical genetics at Columbia University and a plaintiff in the case, said, "With a sole provider, there"s mediocrity." The plaintiffs say that BRCA testing would improve with market competition. Furthermore, some plaintiffs argue that certain natural materials cannot be patented. Jan Nowak, president of the Association for Molecular Pathology and a plaintiff in the case, said, "You can"t patent my DNA, any more than you can patent my right arm, or patent my blood."To date, two government panels, including the National Research Council, found no evidence that gene patents result in significant impediments to research or medical care (Schwartz, New York Times, 5/13).
Researchers at Iowa State University have found that increased expression of a form of cytochrome P-450 (CYP4B1) is a key marker of inhibition of colitis in mice by caffeic acid, an anti-inflammatory antioxidant compound widely distributed in foods. The results, which appear in the June 2009 issue of Experimental Biology and Medicine, implicate CYP4B1, a form of cytochrome P450 previously found to be associated with resolution of allergic inflammation in another model. The normalization of CYP4B1 by caffeic acid treatment was associated with significant lessening of colitic damage, assessed by examining colon histopathology. In comparison with rutin, an anti-inflammatory flavonoid and hypoxoside extract, a botanical known as African potato previously shown to protect against colitis, all three compounds had anti-inflammatory effects, suppressing myeloperoxidase, IL-17 and iNOS and increasing IL-4, known factors associated with inflammation responses. But only caffeic acid protected against the dextran sulfate sodium induced colitis. Its novel mechanism related to CYP4B1 is being studied further. The research team, Zhong Ye, a graduate student in Toxicology, along with Microbiology graduate students Zhiping Liu and Abigail Henderson, Visiting Scientist Kwangwon Lee, Korea University, Dr. Michael Wannemuehler, Veterinary Microbiology, Dr. Jesse Hostetter, a veterinary pathologist, and Dr. Suzanne Hendrich, Toxicologist and Nutritionist, performed studies in 8 week old mice fed the various dietary components and then exposed to dextran sulfate sodium in a mildly irritating dose to induce colitis. Dr. Hendrich noted that "this study of caffeic acid will help us to advance studies of botanicals and plant foods with respect to their ability and mechanisms of inhibiting colitis, and perhaps colon cancer, because colitis increases risk for this disease".
Older women, women with a higher grade of precancerous cells and women who undergo a freezing procedure known as cryotherapy to remove abnormal cervical cells are at a higher risk than other groups that the problem cells will return or develop into cervical cancer, according to a study published in the Journal of the National Cancer Institute, Reuters reports. For the study, Joy Melnikow of the University of California-Davis and colleagues compared 37,000 women who were treated for cervical intraepithelial neoplasia -- abnormal cervical cells -- from 1986 through 2000 with 71,000 women who had no history of abnormal cervical cells.The researchers found that the risk of cervical cancer and recurrence of medium to severe degrees of CIN was highest for women who were older than age 40, who had been previously treated for severe CIN or whose abnormal cells were treated using cryotherapy. The women underwent cone biopsies a surgical procedure to remove abnormal cells were least likely to have a recurrence of CIN. According to Melnikow, recurrence was most likely to occur within the first six years after treatment. Melnikow said that women who have been treated surgically have higher risks of bleeding and preterm labor. Therefore, younger women who are planning to become pregnant might prefer cryotherapy, she said, adding that younger women"s "risk of recurrence is lower, and a recurrence can be treated again" (Steenhuysen, Reuters, 5/12).
It is time to realign research and policy making to promote better sexual
Mice and rabbits immunized with a multimeric-L2 protein vaccine had robust antibody responses and were protected from infection when exposed to human papillomavirus (HPV) type 16 four months after vaccination, according to a new study published in the May 26 online issue of the Journal of the National Cancer Institute.
Neuroscientists feel they are much closer to an accepted unified theory about how the brain processes speech and language, according to a scientist at Georgetown University Medical Center who first laid the concepts a decade ago and who has now published a review article confirming the theory.
Boston Scientific Corporation (NYSE: BSX) announced it has received approval from the U.S. Food and Drug Administration (FDA) to market its TAXUS(R) Liberte(R) Atom(TM) Paclitaxel-Eluting Coronary Stent System, a highly deliverable, next-generation drug-eluting stent (DES) specifically designed for treating small coronary vessels. It was approved for use in vessels as small as 2.25 mm in diameter and joins the TAXUS(R) Express(R) Atom(TM) Stent as the only drug-eluting stents approved for small vessel use in the U.S. The Company plans to begin a full U.S. launch of TAXUS Liberte Atom next month.
A pain condition common in people with migraines also has a high prevalence in patients with cluster headache, according to a study conducted by researchers at the Jefferson Headache Center at Jefferson Hospital for Neuroscience.
Two newspapers recently published opinion pieces on abortion-related public opinion polls. Summaries appear below.~ Steven Kull, Baltimore Sun: Although "many Americans feel morally conflicted about" abortion, it is a "common error to believe that the American electorate is deeply divided about how the government should deal with" the procedure, Kull -- director of WorldPublicOpinion.org and the Program on International Policy Attitudes at the University of Maryland -- writes in a Sun opinion piece. He adds that "there is substantial consensus that the government should not criminalize abortion." According to Kull, a new CNN poll found that 68% of respondents believe Roe v. Wade should not be overturned, and a recent WorldPublicOpinion.org poll found that when asked, "Do you think the government should be involved in trying to discourage abortion or do you think the government should leave these matters to the individual," 69% said that the matter should be left to the individual. Kull adds that "of the 29% who said that the government should be involved in trying to discourage abortions, a remarkably low 8% favored using criminal enforcement methods." According to Kull, other polls have found if "given a middle option -- somewhere between strict prohibition and government permission -- a significant number will choose it." Kull writes that "once the moral question is differentiated from the question of how the government should act, it does appear that there is substantial consensus that abortion should not be criminalized." He concludes, "Once the option of criminal enforcement is taken off the table, constructive options are more likely to emerge and can be an effective focus for the energies freed up from the incessant debates about abortion" (Kull, Baltimore Sun, 5/22).~ Cheryl Wetzstein, Washington Times: "It"s rather ironic that as the most pro-choice government in U.S. history settles into its seats," a Gallup poll "finds that most Americans are pro-life," columnist Wetzstein writes in a Times opinion piece. She adds, "Some observers have tried to pooh-pooh this result, but it doesn"t surprise me for two reasons." Wetzstein writes that her "experience with youth, both personally and professionally, is that they often recoil at abortion," adding, "So I find a pro-life trend in youth to be quite plausible." She continues, "Second, I think some aging baby boomers are changing their views," adding, "People generally become more conservative and self-reflective with age. Legacies matter. Hindsight is 20/20. Regrets appear." Wetzstein concludes, "My suspicion is that in more than a few cases, baby boomers who were willing to have abortions are not at ease with the idea of losing their grandchildren," adding, "It may be that in the autumn of life, being "pro-life" has a whole new meaning" (Wetzstein, Washington Times, 5/26).
Quality of care is not linked to the cost of care, according to a study published last week on the Web site of the journal Health Affairs, CQ HealthBeat reports. For the study, researchers from Dartmouth College and Harvard University analyzed the health care bills of chronically ill Medicare beneficiaries in their last two years of life who received end-of-life care from 2,172 unidentified hospitals. The patients had one of three common conditions: heart attack, pneumonia or congestive heart failure. The study -- sponsored by the National Institute on Aging -- looked at common quality indicators at a hospital-by-hospital level instead of regional level (Norman, CQ HealthBeat, 5/22). Researchers compared the data with some of the quality measures reported on the HHS Hospital Compare Web site (Goldstein, "Health Blog," Wall Street Journal, 5/21). The study found that among the one-fifth of hospitals that spent the least, the cost of end-of-life care was $16,059 on average. In comparison, the cost of end-of-life care at the top 20% of highest-spending hospitals was $34,742 on average. The study also found no link -- or even evidence against a link -- between spending and the quality indicators. The researchers noted that the results might be skewed because the quality indicators they used might penalize hospitals that treat sicker patients. In addition, the study used process-of-care measures instead of patient outcomes. According to CQ HealthBeat, the findings of the study could have an effect on the debate over health care reform legislation because lawmakers and President Obama both have said that a reform plan must be able to control costs and expand access to high-quality, affordable health care (CQ HealthBeat, 5/22).
The drug acyclovir, which suppresses herpes simplex virus-2, does not reduce the risk of HIV transmission when taken by HIV-positive people who also have herpes, according to a study conducted by researchers at the University of Washington, United Press International reports. According to United Press International, genital ulcers associated with HSV-2 are known to increase the risk of HIV transmission. The study was conducted among 3,408 discordant couples, in which one member is HIV-positive and the other is not, at 14 sites in seven African countries: Botswana, Kenya, Rwanda, South Africa, Tanzania, Uganda and Zambia. The primary results of the study found that 41 new HIV cases occurred in the couples in which the HIV-positive member took acyclovir, compared with 43 new infections among the couples who did not take the drug. The results were not statistically significant, according to the researchers (United Press International, 5/13). However, the study did find that acyclovir can slow progression of HIV by 17% in HIV-positive people who also have HSV-2 and whose CD4+ T cell counts are too high to begin antiretroviral therapy. "Although the primary outcome of reducing HIV transmission was not observed, the study yielded important information that will inform HIV prevention research in a number of ways," Connie Celum, a professor of global health and medicine at the University of Washington"s Division of Allergy and Infectious Diseases, said. She added that the "findings will bear fruit for both the HIV prevention and vaccine fields for years to come." The study, called the Partners in Prevention HSV/HIV Transmission Study, was funded by the Bill & Melinda Gates Foundation (University of Washington release, 5/8).
United Auto Workers leaders on Tuesday agreed to accept up to 20% of General Motors stock, as well as concessions on labor rules and retiree health care obligations, as the automaker faces a June 1 deadline to restructure or seek bankruptcy protection, the Detroit News reports (Aguilar/Shepardson, Detroit News, 5/27). Under the deal, the voluntary employees" beneficiary association would receive 17.5% of common GM stock, $6.5 billion of preferred shares, a $2.5 billion note and warrants equal to 2.5% of GM"s stock (Reuters/USA Today, 5/27). In addition, the VEBA would receive $585 million annually in interest income on its preferred stock (Detroit News, 5/27). Another concession included in the tentative deal is the elimination of dental, vision and some prescription drug coverage for hourly retirees (Shepardson/Aguilar, Detroit News, 5/26). UAW also would hold a seat on the GM board of directors (Cho et al., Washington Post, 5/27).Because of a proposed deal announced earlier this month, the Treasury Department and UAW, together, are to own 89% of GM"s stock, meaning that if the UAW-GM deal is approved, the Treasury would own about a 70% share of GM"s stock (Detroit News, 5/26). Current bondholders would hold about a 10% stake in the company (Washington Post, 5/27). The remaining 1% would be held by existing shareholders (Detroit News, 5/26).The total 20% is about half of what was anticipated (Higgins, Detroit Free Press, 5/26). The "significant concessions" made by UAW, which was eligible to receive up to 39% of GM"s equity through the VEBA, "could mean that [GM] is attempting to appease unsecured bondholders, who charged that the UAW was getting a better deal," according to the News (Detroit News, 5/27). UAW said the revised agreement with GM was necessary for the automaker to survive, but the deal will leave hundreds of thousands of GM retirees paying higher out-of-pocket medical expenses, the Wall Street Journal reports (Stoll et al., Wall Street Journal, 5/27).UAW members are scheduled to vote on the agreement on Wednesday and Thursday (Detroit News, 5/26). However, "[e]ven with UAW approval, GM is still likely to file for bankruptcy, since bondholders are unlikely to swallow deep concessions," according to the News (Detroit News, 5/27).
Sedentary behavior is becoming an important component of the exercise and health equation. There is new evidence that prolonged, unbroken sitting time is related to people"s risk of obesity and type 2 diabetes, according to a lecture presented today at the 56th Annual Meeting of the American College of Sports Medicine (ACSM) in Seattle. Examples of sedentary behaviors include watching television, playing video games, using the computer, reading, and doing homework.
Side effects associated with several commonly-prescribed dementia drugs may be putting elderly Canadians at risk, says Queen"s University Geriatrics professor Sudeep Gill.
The majority of men who receive one of the standard treatments for localized prostate cancer - surgery or radiation therapy - have an excellent outcome.
DxS Ltd, a personalized medicine company and leader in the field of companion diagnostics is working in partnership with Exiqon Diagnostics, a company on the forefront of individualizing cancer care through its novel molecular and cell-based oncology clinical laboratory services, to present a timely and relevant workshop on personalized cancer therapy.
Scientists at the Medical Research Council Laboratory of Molecular Biology uncover how an important cancer gene, BRCA1, works by increasing the accuracy with which broken DNA is repaired. Women who inherit a faulty version of the BRCA1 gene are at a higher risk of developing breast or ovarian cancer.
A generation of DNA-like compounds, class R inhibitory oligonucleotides (INH-ODNs), have been shown to effectively inhibit cells responsible for the chronic autoimmune condition lupus. Researchers writing in BioMed Central"s open access journal Arthritis Research & Therapy have demonstrated the anti-inflammatory effects of the INH-ODNs in both in vitro and mouse experiments.
PerkinElmer, Inc., a global leader focused on improving the health and safety of people and the environment, announced the introduction of four new products leveraging the Company"s innovative infrared sensing (IR) and photon detection technologies. Aimed at a range of OEM applications including energy conservation, enhanced home security, and clinical diagnostics applications, the new products will be showcased at the 16th annual Sensor + Test Fair taking place this week in NÃørnberg, Germany.
Watching people"s brains in real time as they handle a set of decision-making problems can reveal how different each person"s strategy can be, according to neuroscientists at the Duke University Medical Center.
Researchers have identified the locking mechanism that allows some neurons to form synapses to pass along essential information. Mutations of genes that produce a critical cell-adhesion molecule involved in the work were previously linked to autism.
Could a holiday in the sun reduce the risk of developing multiple sclerosis? In a recent review for F1000 Medicine Reports, Bridget Bagert and Dennis Bourdette highlight recent advances in potential treatments.